Blocking HIV-1 gp120 at the Phe43 Cavity: If the Extension Fits

摘要

The Phe43 cavity is a mysterious feature in crystallographic structures of HIV-1 gp120-CD4 complexes. In this Structure issue, Acharya and colleagues provide structural explanations for the potent neutralization by CD4 mimetic miniproteins with chemical extensions that fit into this cavity.