Association of Progesterone Receptor Gene (PGR) variants and breast cancer risk in African American Women

摘要

BackgroundProlonged exposure to combined hormone replacement therapy (estrogen plus progestin) increases a woman’s risk of breast cancer whereas estrogen-only hormone replacement therapy does not. This suggests that progesterone may play a role in breast carcinogenesis. Association studies have reported inconsistent relationships between progesterone receptor gene variants and breast cancer.