MR Elastography Derived Shear Stiffness – A New Imaging Biomarker for the Assessment of Early Tumor Response to Chemotherapy

摘要

PurposeThe overall goal is to develop MR Elastography (MRE) derived shear stiffness as a biomarker for the early identification of chemotherapy response, allowing dose, agent type and treatment regimen to be tailored on a per patient basis, improving therapeutic outcome and minimizing normal tissue toxicity. The specific purpose of this study is to test the feasibility of this novel biomarker to measure the treatment response in a well-known chemotherapy model.