Suppression and epigenetic regulation of miR-9 contributes to ethanol teratology: Evidence from zebrafish and murine fetal neural stem cell models

摘要

BackgroundFetal alcohol exposure produces multi-organ defects, making it difficult to identify underlying etiological mechanisms. However, recent evidence for ethanol sensitivity of the miRNA miR-9, suggests one mechanism whereby ethanol broadly influences development. We hypothesized that loss of miR-9 function recapitulates aspects of ethanol teratology.