Alterations in the DNA Methylation Patterns of Calca Timp3 Mmp2 and Igf2r are Associated with Chronic Cystitis in a Cyclophosphamide-induced Mouse Model

摘要

ObjectivesTo determine whether epigenetic changes occurred during cyclophosphamide (CYP)-induced chronic bladder inflammation in mice. Epigenetics plays a role in the regulation of inflammatory genes in non-cancer diseases such as asthma and COPD. However, epigenetic (DNA methylation) changes during chronic bladder inflammation have not been described previously.