Lasting Neurobehavioral Abnormalities in Rats After Neonatal Activation of Serotonin 1A and 1B Receptors: Possible Mechanisms for Serotonin Dysfunction in Autistic Spectrum Disorders

摘要

RationalePerinatal exposure of rats to selective serotonin reuptake inhibitors (SSRIs) produces sensory and social abnormalities paralleling those seen in Autistic Spectrum Disorders (ASD). However, the possible mechanism(s) by which this exposure produces behavioral abnormalities is unclear.