Two-fold Unsymmetrical C-H Functionalization of PyrDipSi-Arenes: A General Method For Synthesis of Substituted meta-Halophenols

摘要

Two-fold unsymmetrical functionalization of arenes, which includes sequential halogenation/oxygenation reactions, has been developed. This transformation allows for a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides. Importantly, the PyrDipSi (2-diisopropylsilylpyrimidine) group can be easily removed or efficiently converted into valuable functionalities.