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Interaction of Disulfiram with Antiretroviral Medications: Efavirenz Increases While Atazanavir Decreases Disulfiram Effect on Enzymes of Alcohol Metabolism

机译：双硫仑与抗逆转录病毒药物的相互作用：依法韦仑增加而阿扎那韦降低了双硫仑对酒精代谢酶的影响。

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Background and ObjectivesAlcohol abuse complicates treatment of HIV disease and is linked to poor outcomes. Alcohol pharmacotherapies, including disulfiram (DIS), are infrequently utilized in co-occurring HIV and alcohol use disorders possibly related to concerns about drug interactions between antiretroviral (ARV) medications and DIS.

机译：背景与目的酗酒使艾滋病毒的治疗复杂化，并与不良后果有关。包括双硫仑（DIS）在内的酒精药物治疗很少用于同时发生的HIV和酒精使用障碍，这可能与对抗逆转录病毒（ARV）药物与DIS之间的药物相互作用有关。

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期刊名称 other
作者
Elinore F McCance-Katz; Valerie A Gruber; George Beatty; Paula Lum; Qing Ma; Robin DiFrancesco; Jill Hochreiter; Paul K Wallace; Morris D Faiman; Gene D Morse;
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作者单位

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年(卷),期 -1(23),2
年度 -1
页码 137–144
总页数 17
原文格式 PDF
正文语种
中图分类
关键词
disulfiram alcohol abuse efavirenz ritonavir atazanavir drug interactions aldehyde dehydrogenase;

机译：双硫仑;酒精滥用;依非韦伦;利托那韦;阿扎那韦;药物相互作用;醛脱氢酶;

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专利

1. Interaction of disulfiram with antiretroviral medications: Efavirenz increases while atazanavir decreases disulfiram effect on enzymes of alcohol metabolism [J] . McCance-KatzE.F., GruberV.A., BeattyG., The American journal on addictions / . 2014,第2期

机译：双硫仑与抗逆转录病毒药物的相互作用：依法韦仑增加，而阿扎那韦降低双硫仑对酒精代谢酶的影响
2. Interactions Between Alcohol and the Antiretroviral Medications Ritonavir or Efavirenz [J] . Elinore F. McCance-Katz, Valerie A. Gruber, George Beatty, Journal of addiction medicine . 2013,第4期

机译：酒精与抗逆转录病毒药物利托那韦或依非韦伦之间的相互作用
3. The use of pH-gradient ion-exchange chromatography to separate sheep liver cytoplasmic aldehyde dehydrogenase from mitochondrial enzyme contamination, and observations on the interaction between the pure cytoplasmic enzyme and disulfiram [J] . F M Dickinson, G J Hart, T M Kitson The biochemical journal . 1981,第3期

机译：使用pH梯度离子交换色谱法将绵羊肝细胞质醛脱氢酶与线粒体酶污染分离，以及对纯细胞质酶与二硫醇之间的相互作用的观察
4. Viscoprene drug delivery system for the sustained release of disulfiram for treatment of alcohol use disorder [C] . Michael Taylor, K Bethany Acampora, Joel T Corbett, World biomaterials congress . 2016

机译：用于持续释放双硫仑的Viscoprene药物输送系统，用于治疗酒精使用障碍
5. Validation of a UPLC-MS/MS method for the simultaneous measurement of the antiretroviral drugs atazanavir, darunavir, efavirenz, etravirine, lopinavir, raltegravir, ritonavir from human plasma. [D] . Patel, Rutva. 2012

机译：用于从人血浆中同时测定抗逆转录病毒药物阿扎那韦，达鲁那韦，依非韦伦，依曲韦林，洛匹那韦，拉格列韦，利托那韦的UPLC-MS / MS方法的验证。
6. Interactions between alcohol and the antiretroviral medications ritonavir or efavirenz [O] . Elinore F. McCance-Katz, Valerie A. Gruber, George Beatty, -1

机译：酒精与抗逆转录病毒药物利托那韦或依非韦伦之间的相互作用
7. Interactions Between Alcohol and the Antiretroviral Medications Ritonavir or Efavirenz [O] . Elinore F. McCance-Katz, Valerie A. Gruber, George Beatty, 2013

机译：酒精和抗逆转录病毒药物之间的相互作用ritonavir或efaviraz
8. Chronic Inhalation Toxicity Study of 1,2-Dichloroethane in Rats Treated with Disulfiram or Ethanol. Part 2. Disposition, Metabolism and Binding Studies [R] . El-hawari, M. , Stoltz, M. , Pallas, F. , 1986

机译：双硫仑或乙醇处理大鼠1,2-二氯乙烷的慢性吸入毒性研究。第2部分。处置，代谢和结合研究

Interaction of Disulfiram with Antiretroviral Medications: Efavirenz Increases While Atazanavir Decreases Disulfiram Effect on Enzymes of Alcohol Metabolism

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