Mechanistic Relationship Between MT1-MMP and the Myocardial Response to Pressure-Overload

摘要

BackgroundWhile matrix metalloproteinases (MMPs) were initially thought to primarily result in extracellular matrix degradation, certain MMP types such as membrane type-1 MMP (MT1-MMP) may also be involved in profibrotic cascades through hydrolysis of latency-associated transforming growth factor (TGF) binding protein (LTBP-1) and activation of TGF dependent profibrotic signaling. The present study tested the hypothesis that MT1-MMP plays a direct role in the matrix remodeling response to a left ventricular (LV) pressure overload (PO) stimulus.