MT1-MMP BICYCLIC PEPTIDE LIGANDS SPECIFIC FOR MT1-MMP

摘要

The present invention relates to polypeptides that are covalently linked to a molecular scaffold such that two or more peptide loops are arranged between attachment points for the scaffold. In particular, the present invention describes peptides that are high affinity binders of membrane type 1 metalloprotease (MT1-MMP). The present invention also describes drug conjugates comprising said peptides conjugated to one or more effectors and / or functional groups used in imaging and targeted cancer therapies.