Optimization of precursor synthesis formulation and stability of 1′-18 F fluoroethyl-β-d-lactose (18 FFEL) for preclinical studies in detection of pancreatic cancer

摘要

Introduction1′-[¹⁸ F]Fluoroethyl-β-d-lactose ([¹⁸ F]FEL) is a new PET imaging agent for early detection of pancreatic cancer and hepatocellular carcinoma. We previously reported the syntheses of [¹⁸ F]FEL using a bromo- and a tosyl- precursor, followed by an improved method using a nosyl-precursor. However, some steps in the synthesis of the precursor appeared to be problematic producing low yields. Here, we report on an optimized method for synthesis of the precursor and production of [¹⁸ F]FEL; we also describe [¹⁸ F]FEL’s formulation and stability.