First In-Mouse Development and Application of a Surgically Relevant Xenograft Model of Ovarian Carcinoma

摘要

PurposePreclinical models of epithelial ovarian cancer have not been exploited to evaluate the clinical standard combination therapy of surgical debulking with follow-up chemotherapy. As surgery is critical to patient survival, here we establish a combined surgical/chemotherapy xenograft model of epithelial ovarian cancer and demonstrate its translational relevance.