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Dorsal MPFC circuitry in rodent models of cocaine use: Implications for drug-addiction therapies

机译:可卡因啮齿动物模型中的背侧MPFC电路:对药物成瘾疗法的影响

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摘要

While the importance of the medial prefrontal cortex (MPFC) in cocaine addiction is well established, its precise contribution to cocaine seeking, taking, and relapse remains incompletely understood. In particular, across two different models of cocaine self-administration, pharmacological or optogenetic activation of the dorsal MPFC has been reported to sometimes promote and sometimes inhibit cocaine seeking. We highlight important methodological differences between the two experimental paradigms, and propose a framework to potentially reconcile the apparent discrepancy. We also draw parallels between these preclinical models of cocaine self-administration and human neuroimaging studies in cocaine users, and argue that both lines of evidence point to dynamic interactions between cue-reactivity processes and control processes within the dorsal MPFC circuitry. From a translational perspective, these findings underscore the importance of interventions and therapeutics targeting not just a brain region, but a specific computational process within that brain region, and may have implications for the design and implementation of more effective treatments for human cocaine addiction.
机译:虽然内侧前额叶皮层(MPFC)在可卡因成瘾中的重要性已得到公认,但其对可卡因寻找,吸收和复发的确切作用仍未完全理解。尤其是,据报道,在两种不同的可卡因自我给药模型中,背侧MPFC的药理或光遗传学激活有时会促进并有时会抑制可卡因的寻找。我们强调了两个实验范式之间重要的方法学差异,并提出了一个可能调和表观差异的框架。我们还在可卡因自我管理的这些临床前临床模型与可卡因使用者中的人类神经影像学研究之间得出了相似之处,并认为这两种证据都表明了提示MPCC回路中提示反应过程与控制过程之间的动态相互作用。从翻译的角度来看,这些发现强调了不仅针对大脑区域,而且针对大脑区域内特定计算过程的干预和疗法的重要性,并且可能对设计和实施更有效的人类可卡因成瘾疗法产生影响。

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