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Targeted Delivery of Doxorubicin-Loaded Poly (ε-caprolactone)-b-Poly (N-vinylpyrrolidone) Micelles Enhances Antitumor Effect in Lymphoma

机译：靶向递送阿霉素负载的聚（ε-己内酯）-b-聚（N-乙烯基吡咯烷酮）胶束可增强淋巴瘤的抗肿瘤作用

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BackgroundThe present study was motivated by the need to design a safe nano-carrier for the delivery of doxorubicin which could be tolerant to normal cells. PCL63-b-PNVP90 was loaded with doxorubicin (6 mg/ml), and with 49.8% drug loading efficiency; it offers a unique platform providing selective immune responses against lymphoma.

机译：背景技术本研究的动机是需要设计一种安全的纳米载体来递送阿霉素，该阿霉素可以耐受正常细胞。 PCL63-b-PNVP90装载了阿霉素（6 mg / ml），药物装载效率为49.8％；它提供了独特的平台，可提供针对淋巴瘤的选择性免疫反应。

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Sumit Kumar Hira; Avnish Kumar Mishra; Biswajit Ray; Partha Pratim Manna;
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年(卷),期 -1(9),4
年度 -1
页码 e94309
总页数 17
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1. Galactose-Decorated Cross-Linked Biodegradable Poly(ethylene glycol)-b-poly(ε-caprolactone) Block Copolymer Micelles for Enhanced Hepatoma-Targeting Delivery of Paclitaxel [J] . Rui Yang, Fenghua Meng, Shoubao Ma Biomacromolecules . 2011,第8期

机译：半乳糖修饰的可交联的可生物降解的聚（乙二醇）-b-聚（ε-己内酯）嵌段共聚物胶束，用于紫杉醇靶向肝癌的增强递送。
2. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. [J] . You Qiang Yang, Bin Zhao, Zhen Dong Li, Acta biomaterialia . 2013,第8期

机译：由多臂星形三嵌段共聚物聚（ε-己内酯）-b-聚（甲基丙烯酸2-（二乙氨基）乙酯）-b-聚（聚乙二醇甲基丙烯酸甲酯）自组装而成的pH敏感胶束控制抗癌药物的传递。
3. pH-sensitive micelles self-assembled from multi-arm star triblock co-polymers poly(ε-caprolactone)-b-poly(2-(diethylamino)ethyl methacrylate)-b-poly(poly(ethylene glycol) methyl ether methacrylate) for controlled anticancer drug delivery. [J] . You Qiang Yang, Bin Zhao, Zhen Dong Li, Acta biomaterialia . 2013,第8期

机译：pH敏感胶束从多臂恒星三嵌段共聚物自组装，聚合物聚（ε-己内酯）-B-聚（2-（二乙基氨基）乙基丙烯酸甲酯）-B-聚（聚（乙二醇）甲基醚甲基丙烯酸酯）受控抗癌药物递送。
4. Synthesis of amphiphilic poly(N-vinylpyrrolidone)-b-poly(ε-caprolactone) block copolymers by a combination of ROP and RAFT [C] . Y. C. Yu, H. W. Kang, D. W. Lee, International Conference on Composite Materials . 2011

机译：通过ROP和RAFT的组合合成两亲吡啶聚（N-乙烯基吡咯烷酮）-B-聚（ε-己内酯）嵌段共聚物
5. Encapsulation of cationic fluorescent dyes and photosensitizers into the nanoscopic domains of Poly(ethylene glycol)-b-poly(epsilon-caprolactone) micelles. [D] . Cao, Zhe. 2016

机译：将阳离子荧光染料和光敏剂封装到聚（乙二醇）-b-聚（ε-己内酯）胶束的纳米域中。
6. Well-Defined Diblock Poly(ethylene glycol)-b-Poly(ε-caprolactone)-Based Polymer-Drug Conjugate Micelles for pH-Responsive Delivery of Doxorubicin [O] . Amin Jafari, Lingyue Yan, Mohamed Alaa Mohamed, 2020

机译：定义明确的基于二嵌段聚（乙二醇）-b-聚（ε-己内酯）的聚合物-药物偶联胶束用于阿霉素的pH响应递送
7. Targeted delivery of doxorubicin-loaded poly (ε-caprolactone)-b-poly (N-vinylpyrrolidone) micelles enhances antitumor effect in lymphoma. [O] . Sumit Kumar Hira, Avnish Kumar Mishra, Biswajit Ray, 2014

机译：靶向递送负载阿霉素的聚（ε-己内酯）-b-聚（N-乙烯基吡咯烷酮）胶束增强淋巴瘤中的抗肿瘤效果。

Targeted Delivery of Doxorubicin-Loaded Poly (ε-caprolactone)-b-Poly (N-vinylpyrrolidone) Micelles Enhances Antitumor Effect in Lymphoma

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