PREFERENCE FOR DISTINCT FUNCTIONAL CONFORMATIONS OF THE DOPAMINE TRANSPORTER ALTERS THE RELATIONSHIP BETWEEN SUBJECTIVE EFFECTS OF COCAINE AND STIMULATION OF MESOLIMBIC DOPAMINE

摘要

BackgroundSubjective effects related to cocaine abuse are primarily mediated by blockade of the dopamine (DA) transporter (DAT). The present study assessed the hypothesis that different conformational equilibria of the DAT regulate differences in extracellular DA induced by structurally diverse DA uptake inhibitors (DUI) and their cocaine-like subjective effects.