African Ancestry Influences CCR5 –2459GA Genotype-Associated Virologic Success of Highly Active Antiretroviral Therapy

摘要

IntroductionIn a North American, HIV-positive, highly active antiretroviral therapy (HAART)-treated, adherent cohort of self-identified white and black patients, we previously observed that chemokine (C-C motif) receptor 5 (CCR5) –2459G>A genotype had a strong association with time to achieve virologic success (TVLS) in black but not in white patients.