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Performance of a 62Zn/62Cu Microgenerator in Kit-Based Synthesis and Delivery of 62CuCu-ETS for PET Perfusion Imaging

机译:62Zn / 62Cu微型发生器在基于套件的PET灌注成像62Cu Cu-ETS合成和输送中的性能

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摘要

The performance of a commercially produced 62Zn/62Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [62Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84 ± 0.23 GBq 62Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [62Cu]Cu-ETS (672 ± 172 MBq) were delivered without difficulty. 62Cu elution yields were high (approximately 90%), accompanied by extremely low 62Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The 62Zn/62Cu microgenerator was a dependable source of short-lived positron-emitting 62Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for “on-demand” delivery of [62Cu]Cu-ETS for PET perfusion imaging.
机译:评估了商业生产的 62 Zn / 62 Cu微型发生器系统的性能以及相关的基于试剂盒的放射性药物合成方法,以用于[ 62]的临床现场生产 Cu] Cu-ETS(乙基乙二醛双(硫代半碳氮酮)铜(II)”,一种用于PET灌注成像的研究药物。在临床使用当天上午9:00,使用37个发生器(包含1.84±0.23 GBq 62 Zn)生成器,总共使用了45个患者剂量的[ 62 Cu] Cu- ETS(672±172 MBq)顺利交付。 62 Cu的洗脱产率很高(约90%),而 62 Zn的穿透率极低(<0.001%)。从洗脱开始到注射时间的放射性药物制剂耗时不到5分钟。 62 Zn / 62 Cu微型发生器是短寿命正电子发射 62 Cu的可靠来源,基于试剂盒的合成证明可以快速,稳定且高度可靠地用于[ 62 Cu] Cu-ETS的“按需”递送,以进行PET灌注成像。

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