Performance of a 62Zn/62Cu Microgenerator in Kit-Based Synthesis and Delivery of 62CuCu-ETS for PET Perfusion Imaging

摘要

The performance of a commercially produced ⁶²Zn/⁶²Cu microgenerator system, and an associated kit-based radiopharmaceutical synthesis method, was evaluated for clinical site production of [⁶²Cu]Cu-ETS (ethylglyoxal bis(thiosemicarbazonato)copper(II)), an investigational agent for PET perfusion imaging. Using 37 generators, containing 1.84 ± 0.23 GBq ⁶²Zn at 9:00 AM on the day of clinical use, a total of 45 patient doses of [⁶²Cu]Cu-ETS (672 ± 172 MBq) were delivered without difficulty. ⁶²Cu elution yields were high (approximately 90%), accompanied by extremely low ⁶²Zn breakthrough (<0.001%). Radiopharmaceutical preparation, from the start-of-elution to time-of-injection, consumed less than five minutes. The ⁶²Zn/⁶²Cu microgenerator was a dependable source of short-lived positron-emitting ⁶²Cu, and the kit-based synthesis proved to be rapid, robust, and highly reliable for “on-demand” delivery of [⁶²Cu]Cu-ETS for PET perfusion imaging.