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3D reconstruction of scintillation light emission from proton pencil beams using limited viewing angles – a simulation study

机译:有限视角下质子笔束闪烁光的3D重建–模拟研究

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摘要

An accurate and high-resolution quality assurance (QA) method for proton radiotherapy beams is necessary to ensure correct dose delivery to the target. Detectors based on a large volume of liquid scintillator have shown great promise in providing fast and high-resolution measurements of proton treatment fields. However, previous work with these detectors has been limited to two-dimensional measurements, and the quantitative measurement of dose distributions was lacking. The purpose of the current study is to assess the feasibility of reconstructing three-dimensional (3D) scintillation light distributions of spot scanning proton beams using a scintillation system. The proposed system consists of a tank of liquid scintillator imaged by charge-coupled device cameras at three orthogonal viewing angles. Because of the limited number of viewing angles, we developed a profile-based technique to obtain an initial estimate that can improve the quality of the 3D reconstruction. We found that our proposed scintillator system and profile-based technique can reconstruct a single energy proton beam in 3D with a gamma passing rate (3%/3 mm local) of 100.0%. For asingle energy layer of an intensity modulated proton therapy prostate treatment plan, the proposed method can reconstruct the 3D light distribution with a gamma pass rate (3%/3 mm local) of 99.7%. In addition, we also found that the proposed method is effective in detecting errors in the treatment plan, indicating that it can be a very useful tool for 3D proton beam QA.
机译:对于质子放射治疗束,需要一种准确,高分辨率的质量保证(QA)方法,以确保将剂量正确地输送到目标。基于大量液体闪烁体的检测器在提供质子治疗领域的快速和高分辨率测量方面显示出巨大的希望。但是,这些检测器的先前工作仅限于二维测量,并且缺乏剂量分布的定量测量。本研究的目的是评估使用闪烁系统重建点扫描质子束的三维(3D)闪烁光分布的可行性。所提出的系统由一个液体闪烁体储罐组成,该储罐由电荷耦合设备的摄像头以三个正交的视角成像。由于视角数量有限,我们开发了一种基于配置文件的技术来获取可以提高3D重建质量的初始估计。我们发现,我们提出的闪烁体系统和基于轮廓的技术可以在3D中以100.0%的伽马通过率(3%/ 3 mm局部)重建单个能量质子束。对于强度调制质子治疗前列腺治疗计划的单个能量层,所提出的方法可以以99.7%的伽玛通过率(3%/ 3 mm局部)重建3D光分布。此外,我们还发现,所提出的方法可有效检测治疗计划中的错误,表明它对于3D质子束QA可能是非常有用的工具。

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