System A Amino Acid Transport-Targeted Brain and Systemic Tumor PET Imaging Agents 2-Amino-3-18FFluoro-2-Methylpropanoic Acid and 3-18FFluoro-2-Methyl-2-(Methylamino)propanoic Acid

摘要

IntroductionAmino acid based radiotracers target tumor cells through increased uptake by membrane-associated amino acid transport (AAT) systems. In the present study, four structurally related non-natural ¹⁸F-labeled amino acids, (R)- and (S)-[¹⁸F]FAMP >1 and (R)- and (S)-[¹⁸F]MeFAMP >2 have been prepared and evaluated in vitro and in vivo for their potential utility in brain and systemic tumor imaging based upon primarily system A transport with positron emission tomography (PET).