Arterial stiffness and wave reflection one year after a pregnancy complicated by hypertension

摘要

Hypertensive disorders of pregnancy (HDP) are associated with cardiovascular disease (CVD) later in life. We investigated the association of HDP with blood pressure (BP) and arterial stiffness 1-year postpartum. Seventy-four participants, 33 with an HDP and 41 with uncomplicated pregnancies, were examined using applanation tonometry to measure BP, carotid-femoral pulse-wave velocity (cfPWV) and augmentation index (AIx). On average, women with HDP had a 9 mm higher systolic BP (p<.01), 0.8 m/s faster cfPWV (p=.09), and 5.4% greater AIx (p=.09) at the 1-year exam. After adjustment for covariates, there was no significant difference in cfPWV between groups, while a 7.3% greater AIx (p<.05) remained. These findings suggest reduced endothelial function may be detected 1 year after HDP. Large prospective studies are needed to further understand of the contribution of arterial stiffness and endothelial dysfunction to the evolution of CVD disease after these complicated pregnancies.