Complete loss of PTEN protein expression correlates with shorter time to brain metastasis and survival in stage IIIB/C melanoma patients with BRAFV600 mutations

摘要

PURPOSELoss of function of PTEN is a frequent event in melanoma, particularly in tumors with BRAF^V600 mutations. The prevalence, pathological features, and clinical outcomes associated with PTEN loss in patients with stage IIIB/C melanoma were interrogated to improve our understanding of the clinical significance of this molecular event.