AN INTER-ICTAL EEG SPECTRAL METRIC FOR TEMPORAL LOBE EPILEPSY LATERALIZATION

摘要

ObjectiveVisually-obvious abnormalities in the resting baseline EEG – slowing, spiking and high-frequency oscillations (HFOs) - are cardinal, though incompletely understood, features of the seizure onset zone in focal epilepsy. We hypothesized that evidence of cortical network dysfunction in temporal lobe epilepsy (TLE) would persist in the absence of visually-classifiable abnormalities in the baseline EEG recorded within the conventional passband, and that metrics of such dysfunction could serve as a lateralizing diagnostic in TLE.