Empiric Weight-Based Vancomycin in Intensive Care Unit Patients with Methicillin-Resistant Staphylococcus Aureus Bacteremia

摘要

BackgroundWe have conducted previous studies in all hospitalized patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia to determine safety and effectiveness of guideline-recommended, weight-based dosing of vancomycin. In these studies, we observed that severely ill patients (Pitt bacteremia score ≥ 4 or ICU patients) were at an increased risk of mortality and/or nephrotoxicity. Therefore, we conducted a subanalysis of the effect of guideline-recommended vancomycin dosing on in-hospital mortality and nephrotoxicity in intensive care unit (ICU) patients with MRSA bacteremia.