Insulin Pump Use and Glycemic Control in Adolescents with Type 1 Diabetes (T1D): Predictors of Change in Method of Insulin Delivery across Two Years

摘要

Few studies have explored durability of insulin pump use, and none have explored the link between depression and pump discontinuation. To examine the relationship between depressive symptoms (measured by the Children’s Depression Inventory, CDI), method of insulin delivery, and A1c, mixed models were used with data from 150 adolescents with T1D and visits every 6 months for 2 years. Of the 63% who used a pump, compared to multiple daily injections (MDI) at baseline, there were higher proportions who were non-minorities, had caregivers with a college degree, private insurance, and two caregivers in the home (p≤0.01). After adjusting for time, sex, age, T1D duration, frequency of blood glucose monitoring, ethnicity, insurance, and caregiver number and education, baseline pump use was associated with −0.79% lower mean A1c (95% CI −1.48, −0.096; p=0.03). For those using a pump at baseline, but switching to MDI during the study (n=9), mean A1c was 1.38% higher (95% CI 0.68, 2.08; p<0.001) than that for those who did not switch method of delivery. A 10-point increase in CDI was associated with a 0.39% increase in A1c (95% CI 0.16, 0.61; p=0.001), independent of pump use. Regarding the temporal relationship between CDI score and changing method of insulin delivery, prior higher CDI score was associated with switching from pump to MDI (OR=1.21; 95% CI 1.05, 1.39 p=0.007). Clinicians should be aware of the associations between depressive symptoms, change in insulin delivery method, and the effect on glycemic control.