A Silver(I)-Catalyzed Intramolecular Ficini’s 2 + 2 Cycloaddition Employing Ynamides

摘要

An intramolecular [2 + 2] cycloaddition using N-sulfonyl substituted ynamides tethered to an enone motif is described here. This thermally driven [2 + 2] cycloaddition manifold can be catalyzed effectively using AgNTf2, and represents the first examples of an intramolecular Ficini reaction.