Evaluation of Antiviral Efficacy of Ribavirin Arbidol and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

摘要

BackgroundMice lacking the type I interferon receptor (IFNAR^−/− mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR^−/− mice by immunohistochemistry and employed the model to evaluate the antiviral efficacy of ribavirin, arbidol, and T-705 against CCHF virus.