Synthesis of Some Benzimidazole Derivatives Bearing 134-Oxadiazole Moiety as Anticancer Agents

摘要

In an effort to establish new benzimidazole related structural leads with improved anticancer activity, several new benzimidazole derivatives (>5a–i) with 1,3,4-oxadiazole scaffold incorporated were synthesized and studied for their anticancer activity. The anticancer screening against MDA-MB-231 breast cancer cell lines showed that compound (>5c) exhibited moderate cytotoxicity.