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PIG-TO-BABOON HETEROTOPIC HEART TRANSPLANTATION – EXPLORATORY PRELIMINARY EXPERIENCE WITH PIGS TRANSGENIC FOR HUMAN THROMBOMODULIN AND COMPARISON OF THREE COSTIMULATION BLOCKADE-BASED REGIMENS

机译：猪到狒狒异种心脏移植-猪血栓素转基因猪的初步实验和三种基于刺激封锁的治疗方案的比较

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BackgroundThree costimulation-blockade-based regimens have been explored after transplantation of hearts from pigs of varying genetic backgrounds to determine whether CTLA4-Ig (abatacept) or anti-CD40mAb+CTLA4-Ig (belatacept) can successfully replace anti-CD154mAb.

机译：背景技术从遗传背景不同的猪移植心脏后，已经研究了三种基于共刺激阻断的方案，以确定CTLA4-Ig（abatacept）或抗CD40mAb + CTLA4-Ig（belatacept）是否可以成功替代抗CD154mAb。

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期刊名称 other
作者
H. Iwase; B. Ekser; V. Satyananda; J. K. Bhama; H. Hara; M. Ezzelarab; E. Klein; R. Wagner; C. Long; J. Thacker; J. Li; H. Zhou; M. Jiang; S. Nagaraju; H. Zhou; M. Veroux; P. Bajona; M. Wijkstrom; Y. Wang; C. Phelps; N. Klymiuk; E. Wolf; D. Ayares; D. K. C. Cooper;
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年(卷),期 -1(22),3
年度 -1
页码 211–220
总页数 20
原文格式 PDF
正文语种
中图分类
关键词
α13-galactosyltransferase gene-knockout baboon complement-regulatory proteins costimulation blockade pig heart thrombomodulin thrombotic microangiopathy xenotransplantation;

机译：α13-半乳糖基转移酶基因敲除;狒狒;补体调节蛋白;协同刺激封锁;猪;心脏;血栓调节蛋白;血栓性微血管病;异种移植;

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专利

1. Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens [J] . Iwase Hayato, Ekser Burcin, Satyananda Vikas, Xenotransplantation . 2015,第3期

机译：猪到狒狒异位心脏移植-人类血栓调节蛋白转基因猪的探索性初步经验以及三种基于共同刺激封锁的方案的比较
2. Different immunosuppressive regimens in preclinical, discordant xenogeneic, heterotopic thoracic pig-to-baboon heart transplantations [J] . Mayr Tanja, Guethoff Sonja, Reichart Bruno, Xenotransplantation . 2015,第Suppla1期

机译：临床前，异种异种，异位胸腔猪到狒狒心脏移植中的不同免疫抑制方案
3. Transgenic Expression in Pig Hearts of Both Human Decay-Accelerating Factor and Human Membrane Cofactor Protein Does Not Provide an Additional Benefit to That of Human Decay-Accelerating Factor Alone in Pig-To-Baboon Xenotransplantation. [J] . Schuurman HJ Transplantation: Official Journal of the Transplantation Society . 2004,第6期

机译：人衰变加速因子和人膜辅助因子蛋白在猪心脏中的转基因表达不能为单独的人衰变加速因子在猪到狒狒异种移植中提供额外的好处。
4. Role of anti-CD40 antibody-mediated costimulation blockade on non-Gal antibod production and heterotopic cardiac xenograft survival in a GTKO.hCD46Tg pig-to-baboon model [O] . Muhammad M. Mohiuddin, Avneesh K. Singh, Philip C. Corcoran, -1

机译：抗CD40抗体介导的共刺激阻断在GTKO.hCD46Tg猪对狒狒模型中非Gal抗体产生和异位心脏异种移植存活中的作用
5. Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens [O] . Hayato Iwase, Burcin Ekser, Vikas Satyananda, 2015

机译：猪至狒狒异位心脏移植 - 人类血统调节素的猪转基因探究性初步体验，并比较了三种成本抑制的封锁方案

PIG-TO-BABOON HETEROTOPIC HEART TRANSPLANTATION – EXPLORATORY PRELIMINARY EXPERIENCE WITH PIGS TRANSGENIC FOR HUMAN THROMBOMODULIN AND COMPARISON OF THREE COSTIMULATION BLOCKADE-BASED REGIMENS

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