Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

Iwase Hayato; Ekser Burcin; Satyananda Vikas; Bhama Jay; Hara Hidetaka; Ezzelarab Mohamed; Klein Edwin; Wagner Robert; Long Cassandra; Thacker Jnanesh; Li Jiang; Zhou Hao; Jiang Maolin; Nagaraju Santosh; Zhou Huidong; Veroux Massimiliano; Bajona Pietro; Wijkstrom Martin; Wang Yi; Phelps Carol; Klymiuk Nikolai; Wolf Eckhard; Ayares David; Cooper David K. C.

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Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

机译：猪到狒狒异位心脏移植-人类血栓调节蛋白转基因猪的探索性初步经验以及三种基于共同刺激封锁的方案的比较

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BackgroundThree costimulation blockade-based regimens have been explored after transplantation of hearts from pigs of varying genetic backgrounds to determine whether CTLA4-Ig (abatacept) or anti-CD40mAb+CTLA4-Ig (belatacept) can successfully replace anti-CD154mAb.

机译：背景技术从遗传背景不同的猪移植心脏后，研究了三种基于共刺激封锁的方案，以确定CTLA4-Ig（abatacept）或抗CD40mAb + CTLA4-Ig（belatacept）能否成功替代抗CD154mAb。

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《Xenotransplantation》 |2015年第3期|共10页
作者
Iwase Hayato; Ekser Burcin; Satyananda Vikas; Bhama Jay; Hara Hidetaka; Ezzelarab Mohamed; Klein Edwin; Wagner Robert; Long Cassandra; Thacker Jnanesh; Li Jiang; Zhou Hao; Jiang Maolin; Nagaraju Santosh; Zhou Huidong; Veroux Massimiliano; Bajona Pietro; Wijkstrom Martin; Wang Yi; Phelps Carol; Klymiuk Nikolai; Wolf Eckhard; Ayares David; Cooper David K. C.;
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正文语种 eng
中图分类器官移植术;
关键词
baboon; complement-regulatory proteins; costimulation blockade; heart; pig; thrombomodulin; thrombotic microangiopathy; xenotransplantation; alpha 1; 3-galactosyltransferase gene-knockout;

机译：狒狒;补体调节蛋白;共刺激阻滞;心脏;猪;血栓调节素;血栓性微血管病;异种移植;alpha 1;3-半乳糖基转移酶基因敲除;

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外文文献

1. Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens [J] . Iwase Hayato, Ekser Burcin, Satyananda Vikas, Xenotransplantation . 2015,第3期

机译：猪到狒狒异位心脏移植-人类血栓调节蛋白转基因猪的探索性初步经验以及三种基于共同刺激封锁的方案的比较
2. Transgenic Expression in Pig Hearts of Both Human Decay-Accelerating Factor and Human Membrane Cofactor Protein Does Not Provide an Additional Benefit to That of Human Decay-Accelerating Factor Alone in Pig-To-Baboon Xenotransplantation. [J] . Schuurman HJ Transplantation: Official Journal of the Transplantation Society . 2004,第6期

机译：人衰变加速因子和人膜辅助因子蛋白在猪心脏中的转基因表达不能为单独的人衰变加速因子在猪到狒狒异种移植中提供额外的好处。
3. Study for Comparison of CD40-mAb and CD40L-Ab Costimulation Blockade after Life-Supporting Orthotopic Cardiac Xenotransplantation of Multi-Transgenic Pig Hearts into Baboons with a Worldwide First Successful Long-Term Survival [J] . Brenner Paolo, Reichart Bruno, Mayr Tanja, Transplantation: Official Journal of the Transplantation Society . 2018,第9Suppla期

机译：CD40-MAB和CD40L-AB共刺激滞后性植物寿命致畸心外膜膜与全球优先成功的长期生存
4. PIG-TO-BABOON HETEROTOPIC HEART TRANSPLANTATION – EXPLORATORY PRELIMINARY EXPERIENCE WITH PIGS TRANSGENIC FOR HUMAN THROMBOMODULIN AND COMPARISON OF THREE COSTIMULATION BLOCKADE-BASED REGIMENS [O] . H. Iwase, B. Ekser, V. Satyananda, -1

机译：猪到狒狒异种心脏移植-猪血栓素转基因猪的初步实验和三种基于刺激封锁的治疗方案的比较
5. Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens [O] . Hayato Iwase, Burcin Ekser, Vikas Satyananda, 2015

机译：猪至狒狒异位心脏移植 - 人类血统调节素的猪转基因探究性初步体验，并比较了三种成本抑制的封锁方案

Pig-to-baboon heterotopic heart transplantation - exploratory preliminary experience with pigs transgenic for human thrombomodulin and comparison of three costimulation blockade-based regimens

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