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Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors

机译：来那度胺可极化Th1特异性抗肿瘤免疫反应并扩展针对各种实体瘤的XBP1抗原特异性中央记忆CD3 + CD8 + T细胞

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摘要

IntroductionEffective combination immunotherapeutic strategies may be required to enhance effector cells’ anti-tumor activities and improve clinical outcomes.

机译：简介可能需要有效的联合免疫治疗策略来增强效应细胞的抗肿瘤活性并改善临床结果。

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期刊名称 other
作者
Jooeun Bae; Derin B Keskin; Kristen Cowens; Ann-Hwee Lee; Glen Dranoff; Nikhil C Munshi; Kenneth C Anderson;
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作者单位

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年(卷),期 -1(3),2
年度 -1
页码 178
总页数 23
原文格式 PDF
正文语种
中图分类
关键词
Combination immunotherapy Lenalidomide XBP1 Antigen-specific cytotoxic T lymphocytes Cancer vaccine;

机译：联合免疫疗法;来那度胺;XBP1;抗原特异性细胞毒性T淋巴细胞;癌症疫苗;

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专利

1. Neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to T and B cells for induction of anti-tumor immunity by allowing generation of immune effector/memory response. [J] . Sarkar K, Goswami S, Roy S, International immunopharmacology . 2010,第8期

机译：印em叶糖蛋白通过允许免疫效应/记忆反应的产生，增强树突状细胞向T和B细胞的癌胚抗原呈递，从而诱导抗肿瘤免疫。
2. Defining the antigen-specific T-cell response to vaccination and poly(I:C)/TLR3 signaling: evidence of enhanced primary and memory CD8 T-cell responses and antitumor immunity. [J] . Salem ML, Kadima AN, Cole DJ, Journal of immunotherapy . 2005,第3期

机译：定义对疫苗接种和poly（I：C）/ TLR3信号传导的抗原特异性T细胞应答：增强的原代和记忆CD8 T细胞应答和抗肿瘤免疫力的证据。
3. Neem leaf glycoprotein promotes dual generation of central and effector memory CD8(+) T cells against sarcoma antigen vaccine to induce protective anti-tumor immunity [J] . Ghosh Sarbari, Sarkar Madhurima, Ghosh Tithi, Molecular Immunology . 2016,第Null期

机译：印em叶糖蛋白促进抗肉瘤抗原疫苗的中央记忆和效应记忆CD8（+）T细胞的双重生成，从而诱导保护性抗肿瘤免疫
4. Photodynamic therapy stimulates anti-tumor immune response in mouse models: the role of regulatory T-cells, anti-tumor antibodies, and immune attack on brain metastases [C] . Fatma Vatansever, Masayoshi Kawakubo, Hoon Chung, Biophotonics and immune responses VIII . 2013

机译：光动力疗法在小鼠模型中刺激抗肿瘤免疫反应：调节性T细胞，抗肿瘤抗体的作用以及对脑转移瘤的免疫攻击
5. IMMUNE RESPONSE TO ULTRAVIOLET-INDUCED TUMORS: TRANSPLANTATION IMMUNITY AND LYMPHOCYTE POPULATIONS EXHIBITING ANTI-TUMOR ACTIVITY (CYTOLYTIC T, CLONES, NATURAL KILLER CELLS). [D] . STREETER, PHILIP REEL. 1985

机译：对紫外线诱导的肿瘤的免疫反应：移植免疫和具有抗肿瘤活性的淋巴细胞（细胞分裂性T，克隆，天然杀伤细胞）。
6. Histone deacetylase (HDAC) inhibitor ACY241 enhances anti-tumor activities of antigen-specific central memory cytotoxic T lymphocytes against multiple myeloma and solid tumors [O] . Jooeun Bae, Teru Hideshima, Yu-Tzu Tai, -1

机译：组蛋白脱乙酰基酶（HDAC）抑制剂ACY241增强抗原特异性中央记忆细胞毒性T淋巴细胞对多发性骨髓瘤和实体瘤的抗肿瘤活性
7. Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses. [O] . Yu-Li Chen, Ming-Cheng Chang, Chi-An Chen, 2012

机译：调节性T淋巴细胞的消耗通过增强抗原特异性T细胞免疫应答来逆转促肿瘤和抗肿瘤免疫之间的不平衡。

Lenalidomide Polarizes Th1-specific Anti-tumor Immune Response and Expands XBP1 Antigen-Specific Central Memory CD3+CD8+ T cells against Various Solid Tumors

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