Human B-Cell and Progenitor Stages As Determined by Probability State Modeling of Multidimensional Cytometry Data

摘要

BackgroundHuman progenitor and B-cell development is a highly regulated process characterized by the ordered differential expression of numerous cell-surface and intra-cytoplasmic antigens. This study investigates the underlying coordination of these modulations by examining a series of normal bone marrow samples with the method of probability state modeling or PSM.