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Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

机译：PI3K / AKT / mTOR途径中的体细胞拷贝数异常和突变对铂治疗的局部晚期或转移性尿路上皮肿瘤的总体生存具有预后意义。

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BackgroundAn integrative analysis was conducted to identify genomic alterations at a pathway level that could predict overall survival (OS) in patients with advanced urothelial carcinoma (UC) treated with platinum-based chemotherapy.

机译：背景进行了综合分析，以鉴定可以预测铂类化学疗法治疗的晚期尿路上皮癌（UC）患者的总体生存（OS）的途径水平的基因组改变。

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期刊名称 other
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Joaquim Bellmunt; Lillian Werner; Jeffrey J. Leow; Stephanie A. Mullane; André P. Fay; Markus Riester; Paul Van Hummelen; Mary-Ellen Taplin; Toni K. Choueiri; Eliezer Van Allen; Jonathan Rosenberg;
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年(卷),期 -1(10),6
年度 -1
页码 e0124711
总页数 16
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1. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway predict tumor response and disease-free survival in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy and radical surgery [J] . Jianhong Peng, Wenjuan Ma, Zhongguo Zhou, Journal of Cancer . 2018,第6期

机译：PI3K / PTEN / AKT / mTOR途径的遗传变异可预测接受术前放化疗和根治性手术的局部晚期直肠癌患者的肿瘤反应和无病生存
2. Novel radiosensitizers for locally advanced epithelial tumors: inhibition of the PI3K/Akt survival pathway in tumor cells and in tumor-associated endothelial cells as a novel treatment strategy? [J] . Riesterer O, Tenzer A, Zingg D, International Journal of Radiation Oncology, Biology, Physics . 2004,第2期

机译：用于局部晚期上皮肿瘤的新型放射增敏剂：抑制肿瘤细胞和与肿瘤相关的内皮细胞中PI3K / Akt生存途径是一种新的治疗策略？
3. Prognostic significance of AKT/mTOR signaling in advanced neuroendocrine tumors treated with somatostatin analogs [J] . Isabel Fernandes, Teresa R Pacheco, Adília Costa, OncoTargets and therapy . 2012,第6期

机译：生长抑素类似物治疗晚期神经内分泌肿瘤中AKT / mTOR信号转导的预后意义
4. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway predict tumor response and disease-free survival in locally advanced rectal cancer patients receiving preoperative chemoradiotherapy and radical surgery [O] . Jianhong Peng, Wenjuan Ma, Zhongguo Zhou, 2018

机译：PI3K / PTEN / AKT / mTOR途径的遗传变异可预测接受术前放化疗和根治性手术的局部晚期直肠癌患者的肿瘤反应和无病生存
5. Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors. [O] . Joaquim Bellmunt, Lillian Werner, Jeffrey J Leow, 2015

机译：pI3K / aKT / mTOR途径中的体细胞拷贝数异常和突变对铂治疗局部晚期或转移性尿路上皮肿瘤的总体存活具有预后意义。

Somatic Copy Number Abnormalities and Mutations in PI3K/AKT/mTOR Pathway Have Prognostic Significance for Overall Survival in Platinum Treated Locally Advanced or Metastatic Urothelial Tumors

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