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Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model

机译：使用气液界面模型去除表皮生长因子或酪氨酸抑制蛋白AG1478可以减少哮喘儿童的杯状细胞和粘液分泌

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RationaleEpithelial remodelling in asthma is characterised by goblet cell hyperplasia and mucus hypersecretion for which no therapies exist. Differentiated bronchial air-liquid interface cultures from asthmatic children display high goblet cell numbers. Epidermal growth factor and its receptor have been implicated in goblet cell hyperplasia.

机译：原理哮喘上皮重塑的特征是杯状细胞增生和粘液分泌过多，尚无治疗方法。来自哮喘儿童的差异性支气管气液界面培养物显示出高杯状细胞数。表皮生长因子及其受体与杯状细胞增生有关。

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期刊名称 other
作者
Jeremy C. Parker; Isobel Douglas; Jennifer Bell; David Comer; Keith Bailie; Grzegorz Skibinski; Liam G. Heaney; Michael D. Shields;
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年(卷),期 -1(10),6
年度 -1
页码 e0129546
总页数 12
原文格式 PDF
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专利

1. Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro. [J] . Partik G, Hochegger K, Schorkhuber M, Journal of Cancer Research and Clinical Oncology . 1999,第7期

机译：tyrphostins A25和AG1478对表皮生长因子受体依赖性信号传导的抑制作用可在体外抑制结直肠肿瘤细胞的生长并诱导其凋亡。
2. Influence of epidermal growth factor receptor inhibitor AG1478 on epithelial-mesenchymal transition in endometrial carcinoma cells. [J] . Yang Yan, Zhihong Ai, Juan Wang, International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2012,第9期

机译：表皮生长因子受体抑制剂AG1478对子宫内膜癌细胞上皮-间质转化的影响。
3. Resolvin D1, but not resolvin E1, transactivates the epidermal growth factor receptor to increase intracellular calcium and glycoconjugate secretion in rat and human conjunctival goblet cells [J] . Kaye Rebecca, Botten Nora, Lippestad Marit, Experimental Eye Research . 2019,第期

机译：reatvin d1，但不是reatvin e1，转移表皮生长因子受体以增加大鼠和人结膜脚卵细胞中的细胞内钙和糖缀合物分泌
4. Imidazole-modified chitosan nanoparticles for delivery to lung epithelial cells in air-liquid interface cultures [C] . Blake Lash, Joscelyn Mejias, Krishnendu Roy Society for Biomaterials annual meeting and exposition . 2017

机译：咪唑修饰的壳聚糖纳米颗粒，用于在气液界面培养中递送至肺上皮细胞
5. The role of epidermal growth factor receptor in hepatocyte growth factor signaling in mammary epithelial cells. [D] . Bonine-Summers, Alyssa Rowena. 2006

机译：表皮生长因子受体在乳腺上皮细胞中肝细胞生长因子信号传导中的作用。
6. Magnetic Nanodrug Delivery Through the Mucus Layer of Air-Liquid Interface Cultured Primary Normal Human Tracheobronchial Epithelial Cells [O] . E. C. Economou, S. Marinelli, M. C. Smith, -1

机译：通过气液界面培养的原代正常人气管支气管上皮细胞粘液层的磁性纳米药物传递。
7. Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model. [O] . Jeremy C Parker, Isobel Douglas, Jennifer Bell, 2015

机译：去除表皮生长因子或Tyrphostin aG1478使用气液界面模型减少来自哮喘儿童的杯状细胞和粘液分泌上皮细胞。

Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model

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