Major Depression (MD) is a highly inherited psychiatric disorder. The norepinephrine transporter (NET) gene plays important role in pathophysiology of MD. This study attempted to examine the relationship between polymorphisms of NET gene and MD.Patients with MD and healthy controls were recruited and subgrouped. The T-182C and G1287A polymorphisms of NET gene were genotyped by direct sequencing. The genotypic and allelic frequencies were compared using the Pearson χ2 analysis. The linkage disequilibrium was analyzed using the UNPHASED program.Significant differences in genotypic and allelic frequencies of T-182C polymorphism were observed between MD subgroups and controls. When referenced by TT genotype, the OR value increased gradient from TC to CC genotype; when referenced by T allele, the odds ratio value of C allele also increased. Compared with those having both −182 T/T and 1287 G/G genotypes, in patients with MD, early-onset MD, and MD with suicide concept group, the −182 C/C and 1287 G/A combinatorial genotype has significant risk; yet in patients with MD family history, the −182 C/C and 1287 A/A combinatorial genotype has significant risk.Different combinations of T-182C and the G1287A polymorphisms of NET gene might increase morbidity risk of MD subpopulations.
展开▼
机译：严重抑郁症（MD）是一种高度遗传的精神病。去甲肾上腺素转运蛋白（NET）基因在MD的病理生理中起重要作用。本研究试图探讨NET基因多态性与MD的关系。招募患有MD的患者和健康对照者并进行分组。通过直接测序对NET基因的T-182C和G1287A多态性进行基因分型。使用Pearsonχ2分析比较基因型和等位基因频率。使用UNPHASED程序分析了连锁不平衡现象。在MD亚组和对照组之间观察到T-182C多态性的基因型和等位基因频率存在显着差异。当以TT基因型为参照时，OR值从TC基因型到CC基因型的梯度增加；当以T等位基因为参考时，C等位基因的比值比值也增加了。与具有−182 T / T和1287 G / G基因型的人相比，患有MD，早发性MD和具有自杀概念组的MD的患者，−182 C / C和1287 G / A组合基因型具有显着风险;然而，在有MD家族史的患者中，−182 C / C和1287 A / A组合基因型具有显着风险.NET基因的T-182C和G1287A多态性的不同组合可能增加MD亚群的发病风险。
展开▼
