Changing Paradigms in the Systemic Treatment of Advanced Cervical Cancer

摘要

Despite availability of primary and secondary prevention measures, cervical cancer persists as one of the most common cancers among women around the world. While early stage disease can be cured with radical and even fertility-sparing surgery, patients with metastatic and recurrent cervical cancer have poor prognosis with historically limited treatment options and incurable disease. Significant advances in cervical cancer treatment have emerged as the result clinical trials seeking to determine the best therapy to prolong overall and progression-free survival. Most recently, trials involving angiogenesis blockade in addition to standard chemotherapy have demonstrated improved overall and progression free survival. This review serves to highlight pivotal trials in chemotherapy development for advanced, metastatic and recurrent cervical cancer including the paradigm-shifting work demonstrating increased overall survival with angiogenesis blockade.