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Early pediatric atopic dermatitis shows only a CLA+ Th2/Th1 imbalance while adults acquire CLA+ Th22/Tc22 subsets

机译：早期的小儿特应性皮炎仅显示CLA + Th2 / Th1不平衡而成年人则获得CLA + Th22 / Tc22亚群

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BackgroundIdentifying differences and similarities between CLA⁺ polarized T-cell subsets in pediatric vs. adult atopic dermatitis (AD) is critical for directing new treatments towards children.

机译：背景识别小儿与成人特应性皮炎（AD）中CLA ^{+ 极化的T细胞亚群之间的差异和相似性对于指导针对儿童的新疗法至关重要。}

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期刊名称 other
作者
Tali Czarnowicki; Hitokazu Esaki; Juana Gonzalez; Dana Malajian; Avner Shemer; Shinji Noda; Sreya Talasila; Adam Berry; Jayla Gray; Lauren Becker; Yeriel Estrada; Hui Xu; Xiuzhong Zheng; James G Krueger; Amy S Paller; Emma Guttman-Yassky;
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年(卷),期 -1(136),4
年度 -1
页码 e3
总页数 22
原文格式 PDF
正文语种
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关键词
Atopic dermatitis T-cell CLA IL-13 IL-22 IFN-γ ICOS CD69 HLA-DR;

机译：特应性皮炎;T细胞;CLA;IL-13;IL-22;IFN-γ;ICOS;CD69;HLA-DR;

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专利

1. Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA) 1 T(H)2/T(H)1 cell imbalance, whereas adults acquire CLA1(+) T(H)22/T(C)22 cell subsets [J] . Czarnowicki Tali, Esaki Hitokazu, Gonzalez Juana, The Journal of Allergy and Clinical Immunology . 2015,第4期

机译：早期小儿特应性皮炎仅显示皮肤淋巴细胞抗原（CLA）1 T（H）2 / T（H）1细胞失衡，而成年人获得CLA1（+）T（H）22 / T（C）22细胞亚群
2. Th1/Th2 Imbalance and Early Age to Transplantation is Associated to Atopic Dermatitis in Heart-Transplanted Pediatric Patients [J] . de Quiros Plaza Esther Bernaldo, Lopez-Abente Jacobo, Camino Manuela, Transplantation: Official Journal of the Transplantation Society . 2018,第9Suppla期

机译：移植的Th1 / Th2不平衡和移植的早年与心脏移植儿科患者的特应性皮炎有关
3. T helper (Th)1, Th17 and Th2 imbalance in mesenchymal stem cells of adult patients with atopic dermatitis: at the origin of the problem [J] . Orciani M., Campanati A., Caffarini M., British Journal of Dermatology . 2017,第6期

机译：T Helper（Th）1，Th17和Th2在成人皮炎的成年患者的间充质干细胞中的不平衡：在问题的起源
4. Arsenic induces Th1/Th2 imbalance in immune and non-immune organs [C] . Y.Y.Guo, L.Zhao, S.Yang International Congress and Exhibition on Arsenic in the Environment . 2019

机译：砷在免疫和非免疫器官中诱导th1 / th2不平衡
5. TH17 cell and its associated cytokines in atopic dermatitis. [D] . Roshdy, Osama. 2009

机译：特应性皮炎中的TH17细胞及其相关细胞因子。
6. Existence of Th22 in children and evaluation of IL-22 + CD4 + T Th17 and other T cell effector subsets from healthy children compared to adults [O] . Erxia Shen, Mengjie Wang, Hairui Xie, 2016

机译：健康儿童与成人相比儿童中Th22的存在以及IL-22 + CD4 + TTh17和其他T细胞效应子集的评估
7. Simultaneous analysis of T helper subsets (Th1, Th2, Th9, Th17, Th22, Tfh, Tr1 and Tregs) markers expression in periapical lesions reveals multiple cytokine clusters accountable for lesions activity and inactivity status [O] . Ana Claudia ARAUJO-PIRES, Carolina Favaro FRANCISCONI, Claudia Cristina BIGUETTI, 2014

机译：同时分析根尖周病变中T辅助子集（Th1，Th2，Th9，Th17，Th22，Tfh，Tr1和Tregs）标志物的表达，揭示多个细胞因子簇对病变活动和不活动状态负责

Early pediatric atopic dermatitis shows only a CLA+ Th2/Th1 imbalance while adults acquire CLA+ Th22/Tc22 subsets

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