INCREASED SUBCORTICAL NEURAL ACTIVITY AMONG HIV+ INDIVIDUALS DURING A LEXICAL RETRIEVAL TASK

摘要

BackgroundDeficits in lexical retrieval, present in approximately 40% of HIV+ patients, are thought to reflect disruptions to frontal-striatal functions and may worsen with immunosuppression. Coupling frontal-striatal tasks such as lexical retrieval with functional neuroimaging may help delineate the pathophysiologic mechanisms underlying HIV-associated neurological dysfunction.