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DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

机译：DNA修复缺陷和奥拉帕比在转移性前列腺癌中的作用

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BACKGROUNDProstate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP) inhibition with olaparib.

机译：背景技术前列腺癌是一种异质性疾病，但是目前的治疗方法并非基于分子分层。我们假设具有DNA修复缺陷的转移性，去势抵抗性前列腺癌将对olaparib抑制聚二磷酸腺苷[ADP]-核糖）聚合酶（PARP）产生反应。

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期刊名称 other
作者
J. Mateo; S. Carreira; S. Sandhu; S. Miranda; H. Mossop; R. Perez-Lopez; D. Nava Rodrigues; D. Robinson; A. Omlin; N. Tunariu; G. Boysen; N. Porta; P. Flohr; A. Gillman; I. Figueiredo; C. Paulding; G. Seed; S. Jain; C. Ralph; A. Protheroe; S. Hussain; R. Jones; T. Elliott; U. McGovern; D. Bianchini; J. Goodall; Z. Zafeiriou; C.T. Williamson; R. Ferraldeschi; R. Riisnaes; B. Ebbs; G. Fowler; D. Roda; W. Yuan; Y.-M. Wu; X. Cao; R. Brough; H. Pemberton; R. A’Hern; A. Swain; L.P. Kunju; R. Eeles; G. Attard; C.J. Lord; A. Ashworth; M.A. Rubin; K.E. Knudsen; F.Y. Feng; A.M. Chinnaiyan; E. Hall; J.S. de Bono;
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年(卷),期 -1(373),18
年度 -1
页码 1697–1708
总页数 20
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专利

1. Moving Beyond the Androgen Receptor in Advanced Prostate Cancer Commentary on: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer [J] . Chedgy Edmund C. P., Black Peter C. Urology . 2016,第Null期

机译：超越高级前列腺癌症评论中的雄激素受体：DNA修复缺陷和奥拉帕里布在转移前列腺癌中
2. Moving Beyond the Androgen Receptor in Advanced Prostate Cancer Commentary on: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer [J] . Chedgy Edmund C. P., Black Peter C. Urology . 2016,第Null期

机译：在晚期前列腺癌中超越雄激素受体的评论：转移性前列腺癌中的DNA修复缺陷和奥拉帕里布
3. Re: DNA-repair Defects and Olaparib in Metastatic Prostate Cancer [J] . Witjes Wim P. J. European urology . 2016,第1期

机译：回复：转移性前列腺癌的DNA修复缺陷和奥拉帕比
4. Identification of Circulating Pluripotent Cancer Stem Cells in the Blood of Prostate Cancer Patients for the Diagnosis of Metastatic Cancer [C] . Anette Claudia Schafer, Yawen Ju, Youngbin Tak, International Molecular Medicine Tri-Conference. . 2016

机译：鉴定前列腺癌患者血液中循环多能癌症干细胞诊断转移性癌症
5. 3D spheroid culture systems for metastatic prostate cancer dormancy studies and anti-cancer therapeutics development. [D] . Hsiao, Amy Yu-Ching. 2011

机译：用于转移性前列腺癌休眠研究和抗癌疗法开发的3D球体培养系统。
6. Ipilimumab plus nivolumab and DNA-repair defects in AR-V7-expressing metastatic prostate cancer [O] . Karim Boudadi, Daniel L. Suzman, Valsamo Anagnostou, 2018

机译：Ipilimumab加nivolumab和表达AR-V7的转移性前列腺癌的DNA修复缺陷
7. Getting personal with prostate cancer:DNA-repair defects and olaparib in metastatic prostate cancer [O] . Raison, Nicholas, Elhage, Oussama, Dasgupta, Prokar 2016

机译：认识前列腺癌：转移性前列腺癌中的DNA修复缺陷和olaparib

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer

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