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Combined TLR7/8 and TLR9 Ligands Potentiate the Activity of a Schistosoma japonicum DNA Vaccine

机译：结合的TLR7 / 8和TLR9配体增强了日本血吸虫DNA疫苗的活性。

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BackgroundToll-like receptor (TLR) ligands have been explored as vaccine adjuvants for tumor and virus immunotherapy, but few TLR ligands affecting schistosoma vaccines have been characterized. Previously, we developed a partially protective DNA vaccine encoding the 26-kDa glutathione S-transferase of Schistosoma japonicum (pVAX1-Sj26GST).

机译：背景技术已经研究了Toll样受体（TLR）配体作为用于肿瘤和病毒免疫疗法的疫苗佐剂，但是很少有影响血吸虫疫苗的TLR配体被表征。以前，我们开发了一种部分保护性DNA疫苗，编码日本血吸虫的26 kDa谷胱甘肽S-转移酶（pVAX1-Sj26GST）。

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期刊名称 PLoS Neglected Tropical Diseases
作者
Xuefeng Wang; Liyang Dong; Hongchang Ni; Sha Zhou; Zhipeng Xu; Jason Shih Hoellwarth; Xiaojun Chen; Rongbo Zhang; Qiaoyun Chen; Feng Liu; Jun Wang; Chuan Su;
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年(卷),期 2013(7),4
年度 2013
页码 e2164
总页数 13
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学 ; 医学寄生虫学 ;
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专利

1. Combined TLR7/8 and TLR9 Ligands Potentiate the Activity of a Schistosoma japonicum DNA Vaccine [J] . Xuefeng Wang, Liyang Dong, Hongchang Ni, PLOS Neglected Tropical Diseases . 2013 ,第4期

机译：结合的TLR7 / 8和TLR9配体增强了日本血吸虫DNA疫苗的活性。
2. pDC Activation by TLR7/8 Ligand CL097 Compared to TLR7 Ligand IMQ or TLR9 Ligand CpG [J] . Jing Wu, Shuang Li, Tete Li, Journal of immunology research. . 2019 ,第1期

机译：通过TLR7 / 8配体CL097的PDC活化与TLR7配体IMQ或TLR9配体CPG相比
3. Gene Gun Bombardment with DNA-Coated Golden Particles Enhanced the Protective Effect of a DNA Vaccine Based on Thioredoxin Glutathione Reductase of Schistosoma japonicum [J] . Yan Cao, Bin Zhao, Yanhui Han, BioMed research international . 2013 ,第Pta3期

机译：具有DNA涂层的金黄颗粒的基因枪轰击，增强了基于血吸虫的血吸虫血清素谷胱甘肽还原酶的DNA疫苗的保护作用
4. Oral immunization with a schistosoma haematobium dna vaccine encapsulated in microparticles [C] . B.Baras, L.Dupre, A.Capron, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 2000

机译：用微粒包裹的血吸虫血红蛋白脱氧核糖核酸疫苗进行口服免疫
5. Structure-activity relationships of ruthenium(II) polypyridyl complexes with redox-active intercalating ligands: Correlation between redox activity, DNA cleavage capability and cytotoxicity. [D] . Narh, Eugenia Soyo. 2015

机译：钌（II）聚吡啶基配合物与氧化还原活性的嵌入配体的结构活性关系：氧化还原活性，DNA裂解能力和细胞毒性之间的相关性。
6. Combined IL-12 Plasmid and Recombinant SjGST Enhance the Protective and Anti-pathology Effect of SjGST DNA Vaccine Against Schistosoma japonicum [O] . Po-Ching Cheng, Ching-Nan Lin, Shih-Yi Peng, 2016

机译：IL-12质粒和重组SjGST的结合增强了SjGST DNA疫苗对日本血吸虫的保护和抗病理作用
7. Combined TLR7/8 and TLR9 ligands potentiate the activity of a Schistosoma japonicum DNA vaccine. [O] . Xuefeng Wang, Liyang Dong, Hongchang Ni, 2013

机译：组合的TLR7 / 8和TLR9配体增强日本血吸虫DNa疫苗的活性。

Combined TLR7/8 and TLR9 Ligands Potentiate the Activity of a Schistosoma japonicum DNA Vaccine

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