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Lymphatic Vessels Inflammation and Immunity in Skin Cancer

机译:皮肤癌中的淋巴管炎症和免疫

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摘要

Skin is a highly ordered immune organ that coordinates rapid responses to external insult while maintaining self-tolerance. In healthy tissue, lymphatic vessels drain fluid and coordinate local immune responses; however, environmental factors induce lymphatic vessel dysfunction, leading to lymph stasis and perturbed regional immunity. These same environmental factors drive the formation of local malignancies, which are also influenced by local inflammation. Herein, we discuss clinical and experimental evidence supporting the tenet that lymphatic vessels participate in regulation of cutaneous inflammation and immunity, are important contributors to malignancy and potential biomarkers and targets for immunotherapy.
机译:皮肤是高度有序的免疫器官,可协调对外部侮辱的快速反应,同时保持自我容忍。在健康组织中,淋巴管排出液体并协调局部免疫反应。然而,环境因素会导致淋巴管功能障碍,导致淋巴淤滞和局部免疫功能紊乱。这些相同的环境因素驱动局部恶性肿瘤的形成,其也受局部炎症的影响。在这里,我们讨论支持淋巴管参与皮肤炎症和免疫调节的宗旨的临床和实验证据,它们是恶性肿瘤的重要贡献者以及潜在的生物标记物和免疫疗法的靶标。

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