Plasma IL-10 levels to guide antiviral prophylaxis prevention of late-onset cytomegalovirus disease in high risk solid kidney and liver transplant recipients

摘要

BackgroundImmune-measurements that distinguish SOT recipients who control CMV infection from those who progress to CMV-disease (CMV-dz) may be clinically useful in guiding tailored prevention strategies. We previously reported that elevated plasma levels of the immune-modulator IL-10 are associated with late CMV-dz. Here we evaluate whether IL-10 levels measured soon after prophylaxis discontinuation are predictive of CMV-dz risk.