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Feature Screening in Ultrahigh Dimensional Coxs Model

机译:超高维Cox模型中的特征筛选

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摘要

Survival data with ultrahigh dimensional covariates such as genetic markers have been collected in medical studies and other fields. In this work, we propose a feature screening procedure for the Cox model with ultrahigh dimensional covariates. The proposed procedure is distinguished from the existing sure independence screening (SIS) procedures (, ) in that the proposed procedure is based on joint likelihood of potential active predictors, and therefore is not a marginal screening procedure. The proposed procedure can effectively identify active predictors that are jointly dependent but marginally independent of the response without performing an iterative procedure. We develop a computationally effective algorithm to carry out the proposed procedure and establish the ascent property of the proposed algorithm. We further prove that the proposed procedure possesses the sure screening property. That is, with the probability tending to one, the selected variable set includes the actual active predictors. We conduct Monte Carlo simulation to evaluate the finite sample performance of the proposed procedure and further compare the proposed procedure and existing SIS procedures. The proposed methodology is also demonstrated through an empirical analysis of a real data example.
机译:在医学研究和其他领域中,已经收集了具有超高维协变量(例如遗传标记)的生存数据。在这项工作中,我们提出了具有超高维协变量的Cox模型的特征筛选程序。拟议的程序与现有的确定独立性筛选(SIS)程序(,)有所不同,因为拟议的程序基于潜在主动预测变量的联合可能性,因此不是边际筛选程序。所提出的过程可以有效地识别活跃的预测变量,这些预测变量共同依赖于响应,但在某种程度上与响应无关,而无需执行迭代过程。我们开发了一种计算有效的算法来执行所提出的程序并建立所提出算法的上升特性。我们进一步证明所提出的程序具有确定的筛选性质。即,随着概率趋于一,所选择的变量集包括实际的活动预测变量。我们进行蒙特卡洛模拟,以评估所提出程序的有限样本性能,并进一步比较所提出的程序和现有的SIS程序。通过对真实数据示例的经验分析也证明了所提出的方法。

著录项

  • 期刊名称 other
  • 作者单位
  • 年(卷),期 -1(26),-1
  • 年度 -1
  • 页码 881–901
  • 总页数 31
  • 原文格式 PDF
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