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Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept on Multiple Sclerosis

机译：基于代谢体素的快速3D-MRSI对整个人脑的分析：多发性硬化症的概念证明

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摘要

PurposeUsing optimized fast volumic echo planar spectroscopic imaging (3D-EPSI), we aimed to detect local metabolic abnormalities over the complete human brain in multiple sclerosis patients.

机译：目的使用优化的快速体积回波平面光谱成像（3D-EPSI），我们旨在检测多发性硬化症患者整个人脑的局部代谢异常。

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期刊名称 other
作者
Maxime Donadieu; Yann Le Fur; Angèle Lecocq; Andrew A. Maudsley; Soraya Gherib; Elisabeth Soulier; Sylviane Confort-Gouny; Fanelly Pariollaud; Marie-Pierre Ranjeva; Jean Pelletier; Maxime Guye; Wafaa Zaaraoui; Bertrand Audoin; Jean-Philippe Ranjeva;
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年(卷),期 -1(44),2
年度 -1
页码 411–419
总页数 17
原文格式 PDF
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关键词
Proton Magnetic resonance spectroscopic imaging Multiple Sclerosis whole brain statistical mapping analysis neurodegeneration inflammation;

机译：质子磁共振波谱成像;多发性硬化症;全脑;统计作图分析;神经变性;炎症;

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专利

1. Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis [J] . Donadieu Maxime, Le Fur Yann, Lecocq Angele, Journal of magnetic resonance imaging: JMRI . 2016,第2期

机译：基于代谢体素的快速3D-MRSI对整个人脑的分析：多发性硬化症的概念证明
2. Clinical Correlations of Brain Lesion Location in Multiple Sclerosis: Voxel-Based Analysis of a Large Clinical Trial Dataset [J] . Anna Altermatt, Laura Gaetano, Stefano Magon, Brain topography . 2018,第5期

机译：多发性硬化症脑病变位置的临床相关性：基于体素的大型临床试验数据集分析
3. Brain perfusion imaging with voxel-based analysis in secondary progressive multiple sclerosis patients with a moderate to severe stage of disease: a boon for the workforce [J] . Mina Taghizadeh Asl, Reza Nemati, Negar Chabi, BMC Neurology . 2016,第1期

机译：患有中度至重度疾病的继发进行性多发性硬化症患者的基于脑素分析的脑灌注成像：劳动力的福音
4. A voxel-based electrostatic field analysis for the virtual-human model Duke using the indirect boundary element method with a GPU-accelerated fast multipole method [C] . S. Hamada International Conference on Boundary Elements and Other Mesh Reduction Methods . 2014

机译：使用间接边界元法用GPU加速快速多极法的虚拟人模型Duke基于体素的静电场分析
5. Oxidative Stress and Proteomic Studies of Mammalian Models of Age-Related Metabolic Dysfunction in Neurodegenerative Disorders: (1) Upregulation of Pin1 in Alzheimer Mouse Model (2) Analysis of Brain Post-Intranasal Administration of Insulin in Alzheimer and Induced Diabetic Mouse Models (3) Analysis Of Proteome Changes In The Parietal Lobule Of Rhesus Monkey Non-Human Primate Following Resveratrol Supplementation as a Part of a Western-Diet. [D] . Swomley, Aaron Michael. 2017

机译：氧化应激和蛋白质组学研究的神经退行性疾病的年龄相关代谢功能障碍的哺乳动物模型：（1）阿尔茨海默病小鼠模型中Pin1的上调（2）鼻内注射胰岛素对老年性痴呆症小鼠和诱导的糖尿病小鼠模型的分析（3）白藜芦醇补充作为西方饮食的一部分，恒河猴非人类灵长类动物顶叶小叶蛋白质组变化的分析。
6. CD206-Targeted Liposomal Myelin Basic Protein Peptides in Patients with Multiple Sclerosis Resistant to First-Line Disease-Modifying Therapies: A First-in-Human Proof-of-Concept Dose-Escalation Study [O] . Alexey Belogurov Jr., Konstantin Zakharov, Yakov Lomakin, 2016

机译：抗一线疾病修饰疗法的多发性硬化患者中以CD206为靶点的脂质体髓鞘碱性蛋白肽：一项首次在人类中进行概念验证的剂量递增研究
7. Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept in multiple sclerosis [O] . Donadieu, Maxime, Le Fur, Yann, Lecocq, Angèle, 2016

机译：基于代谢体素的快速3D-MRSI对整个人脑的分析：多发性硬化症的概念证明

Metabolic voxel-based analysis of the complete human brain using fast 3D-MRSI: Proof of concept on Multiple Sclerosis

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