Fibroblast Growth Factor-23 and Chronic Allograft Injury in Pediatric Renal Transplant Recipients: a Midwest Pediatric Nephrology Consortium Study

摘要

BackgroundThe chronic kidney disease-mineral bone disorder (CKD-MBD) produces fibroblast growth factor-23 (FGF23) and related circulating pathogenic factors that are strongly associated with vascular injury and declining kidney function in native CKD. Similarly, chronic renal allograft injury (CRAI) is characterized by vascular injury and declining allograft function in transplant CKD. We hypothesized that circulating CKD-MBD factors could serve as non-invasive biomarkers of CRAI.