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The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells

机译：全反式维甲酸诱导的视黄酸受体β在培养的ARPE-19细胞中表达骨形态发生蛋白2和基质金属蛋白酶2

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PurposeAll-trans retinoic acid (ATRA) plays an important role in ocular development. Previous studies found that retinoic acid could influence the metabolism of scleral remodeling by promoting retinal pigment epithelium (RPE) cells to secrete secondary signaling factors. The purpose of this study was to investigate whether retinoic acid affected secretion of bone morphogenetic protein 2 (BMP-2) and matrix metalloproteinase 2 (MMP-2) and to explore the signaling pathway of retinoic acid in cultured acute retinal pigment epithelial 19 (ARPE-19) cells.

机译：目的全反式维甲酸（ATRA）在眼部发育中起重要作用。先前的研究发现，视黄酸可以通过促进视网膜色素上皮细胞（RPE）分泌次级信号转导因子来影响巩膜重塑的代谢。这项研究的目的是调查视黄酸是否会影响骨形态发生蛋白2（BMP-2）和基质金属蛋白酶2（MMP-2）的分泌，并探讨视黄酸在培养的急性视网膜色素上皮19（ARPE）中的信号传导途径。 -19）细胞。

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Zhenya Gao; Lijun Huo; Dongmei Cui; Xiao Yang; Junwen Zeng;
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年(卷),期 -1(11),3
年度 -1
页码 e0150831
总页数 13
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1. The Antagonist of Retinoic Acid Receptor α, ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation [J] . Siqian Wang, Wenjuan Bi, Yi Liu, Drug Design, Development and Therapy . 2020,第1期

机译：视黄酸受体α的拮抗剂，ER-50891拮抗全反式视黄酸的抑制作用，拯救骨形态发生蛋白2诱导的骨纤维素分化
2. Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis [J] . Yuan-Han Qin, Feng-Ying Lei, Peng Hu, Pediatric Nephrology . 2009,第8期

机译：全反式维甲酸对肾小球硬化症大鼠肾组织基质金属蛋白酶-2，基质金属蛋白酶9和组织金属蛋白酶-1表达的影响
3. Effect of all-trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis. [J] . Qin YH, Lei FY, Hu P Pediatric nephrology: journal of the International Pediatric Nephrology Association . 2009,第8期

机译：全反式维甲酸对肾小球硬化大鼠肾组织基质金属蛋白酶-2，基质金属蛋白酶-9和组织金属蛋白酶-1表达的影响。
4. Osteogenic Differentiation of Mouse Adipose-Derived Stromal Cells Requires Retinoic Acid and Bone Morphogenetic Protein Type IB Signaling [C] . D.C. WAN, Y.Y. SHI, R.P. NACAMULI, International Society of Craniofacial Surgery . 2007

机译：小鼠脂肪衍生的基质细胞的成骨分化需要视黄酸和骨形态发生蛋白类型IB信号传导
5. Retinoic acid transfer and protein-protein interaction between the cellular retinoic acid binding protein and the retinoic acid receptor probed by hydrogen deuterium exchange mass spectrometry. [D] . Sjoelund, Virginie. 2009

机译：氢氘交换质谱法检测细胞视黄酸结合蛋白与视黄酸受体之间的视黄酸转移和蛋白相互作用。
6. The Antagonist of Retinoic Acid Receptor α ER-50891 Antagonizes the Inhibitive Effect of All-Trans Retinoic Acid and Rescues Bone Morphogenetic Protein 2-Induced Osteoblastogenic Differentiation [O] . Siqian Wang, Wenjuan Bi, Yi Liu, 2020

机译：维甲酸受体α的拮抗剂ER-50891拮抗全反式维甲酸的抑制作用并挽救骨形态发生蛋白2诱导的成骨细胞分化
7. The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells. [O] . Zhenya Gao, Lijun Huo, Dongmei Cui, 2016

机译：全反式维甲酸诱导的aRpE-19细胞中维甲酸受体β对骨形态发生蛋白2和基质金属蛋白酶2的表达。

The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells

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