Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1288a-tetrahydrocyclopropacimidazolo45-eindol-4-one-6-carboxylate (CImI) alkylation subunit

摘要

The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.