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Generalizing Quantile Regression for Counting Processes with Applications to Recurrent Events

机译:通用分位数回归用于计数过程及其在递归事件中的应用

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摘要

In survival analysis, quantile regression has become a useful approach to account for covariate effects on the distribution of an event time of interest. In this paper, we discuss how quantile regression can be extended to model counting processes, and thus lead to a broader regression framework for survival data. We specifically investigate the proposed modeling of counting processes for recurrent events data. We show that the new recurrent events model retains the desirable features of quantile regression such as easy interpretation and good model flexibility, while accommodating various observation schemes encountered in observational studies. We develop a general theoretical and inferential framework for the new counting process model, which unifies with an existing method for censored quantile regression. As another useful contribution of this work, we propose a sample-based covariance estimation procedure, which provides a useful complement to the prevailing bootstrapping approach. We demonstrate the utility of our proposals via simulation studies and an application to a dataset from the US Cystic Fibrosis Foundation Patient Registry (CFFPR).
机译:在生存分析中,分位数回归已成为解决协变量对关注事件时间分布的影响的有用方法。在本文中,我们讨论了如何将分位数回归扩展到模型计数过程,从而为生存数据提供更广泛的回归框架。我们专门研究针对重复事件数据的计数过程的建议建模。我们表明,新的复发事件模型保留了分位数回归的理想功能,例如易于解释和良好的模型灵活性,同时适应了观测研究中遇到的各种观测方案。我们为新的计数过程模型开发了一个通用的理论和推论框架,该框架与现有的审查分位数回归方法相结合。作为这项工作的另一个有用贡献,我们提出了一个基于样本的协方差估计程序,该程序为流行的自举方法提供了有用的补充。我们通过模拟研究和我们对美国囊性纤维化基金会患者注册系统(CFFPR)的数据集的应用,证明了我们的建议的实用性。

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