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Effect of Arched Leaflets and Stent Profile on the Hemodynamics of Tri-leaflet Flexible Polymeric Heart Valves

机译:弓形小叶和支架轮廓对三叶柔性聚合物心脏瓣膜血流动力学的影响

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摘要

Polymeric heart valves (PHV) can be engineered to serve as alternatives for existing prosthetic valves due to higher durability and hemodynamics similar to bioprosthetic valves. The purpose of this study is to evaluate the effect of geometry on PHVs coaptation and hemodynamic performance. The two geometric factors considered are stent profile and leaflet arch length, which were varied across six valve configurations. Three models were created with height to diameter ratio of 0.6, 0.7, and 0.88. The other three models were designed by altering arch height to stent diameter ratio, to be 0, 0.081, and 0.116. Particle image velocimetry (PIV) experiments were conducted on each PHV to characterize velocity, vorticity, turbulent characteristics, effective orifice area (EOA), and regurgitant fraction. This study revealed that the presence of arches as well as higher stent profile reduced regurgitant flow down to 5%, while peak systole downstream velocity reduced to 58% and Reynolds Shear Stress values reduced 40%. Further, earlier reattachment of the forward flow jet was observed in PHVs with leaflet arches. These findings indicate that although both geometric factors help diminish the commissural gap during diastole, leaflet arches induce a larger jet opening, yielding to earlier flow reattachment and lower energy dissipation.
机译:高分子心脏瓣膜(PHV)可以设计成可替代现有人工瓣膜,因为它具有更高的耐用性和类似于生物人工瓣膜的血液动力学特性。这项研究的目的是评估几何形状对PHV接合和血液动力学性能的影响。所考虑的两个几何因素是支架轮廓和小叶弓长度,它们在六个瓣膜配置中有所不同。创建了三个模型,高度与直径之比为0.6、0.7和0.88。其他三个模型是通过将足弓高度与支架直径之比更改为0、0.081和0.116来设计的。在每个PHV上进行了粒子图像测速(PIV)实验,以表征速度,涡度,湍流特性,有效孔面积(EOA)和反流分数。这项研究表明,弓的存在以及较高的支架轮廓可将反流流量降低至5%,而最大收缩期下游速度降低至58%,雷诺剪切应力值降低40%。此外,在带有小叶弓的PHV中观察到更早地重新安装了前向喷流。这些发现表明,尽管这两个几何因素都有助于减少舒张期的合缝间隙,但小叶弓形会引起较大的射流张开,从而导致较早的血流重新附着和较低的能量耗散。

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