HYPOTHERMIA for NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY: NICHD NEONATAL RESEARCH NETWORK CONTRIBUTION to the FIELD

摘要

In this chapter we summarize the NICHD Neonatal Research Network (NRN) trial of whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy in relation to other randomized controlled trials (RCTs) of hypothermia neuroprotection. We describe the NRN secondary studies that have been published in the last 10 years evaluating clinical, genetic, biochemical and imaging biomarkers of outcome.