Characteristics associated with virologic failure in high-risk HIV-positive participants with prior failure: a post-hoc analysis of ACTG 5251

摘要

Patients with prior virologic failure are at increased risk of subsequent failure, emergence of resistance, and death. This analysis identifies outcomes and correlates of virologic failure in a high-risk population.MethodsA5251 was designed to evaluate an enhanced adherence counseling intervention delivered by nurses from a central call site on virologic suppression. Due to slow enrollment, the study was closed prematurely and revised study endpoints were evaluated (week-24 virologic failure (HIV-1 RNA ≥ 200 copies/ml) and non-perfect adherence (<100% self-reported using both the ACTG adherence questionnaire and visual analog scale (VAS)).